HSF1 and Molecular Chaperones in Biology and Disease (Advances in Experimental Medicine and Biology (1243), Band 1243)
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HSF1 and Molecular Chaperones in Biology and Cancer
~EN HC NWISBN: 9783030402037 bzw. 3030402037, vermutlich in Englisch, Springer Nature, gebundenes Buch, neu.
Lieferung aus: Schweiz, Lagernd.
Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. Hard cover.
Protein homeostasis, or “Proteostasis”, lies at the heart of human health and disease. From the folding of single polypeptide chains into functional proteins, to the regulation of intracellular signaling pathways, to the secreted signals that coordinate cells in tissues and throughout the body, the proteostasis network operates to support cell health and physiological fitness. However, cancer cells also hijack the proteostasis network and many of these same processes to sustain the growth and spread of tumors. The chapters in this book are written by world experts in the many facets of the proteostasis network. They describe cutting-edge insights into the structure and function of the major chaperone and degradation systems in healthy cells and how these systems are co-opted in cancer cells and the cells of the tumor microenvironment. The chapters also cover therapeutic interventions such as the FDA-approved proteasome inhibitors Velcade and Krypolis as well as other therapies currently under clinical investigation to disarm the ability of the proteostasis network to support malignancy. This compendium is the first of its kind and aims to serve as a reference manual for active investigators and a primer for newcomers to the field. This book is dedicated to the memory of Susan Lindquist, a pioneer of the proteostasis field and a champion of the power of basic scientific inquiry to unlock the mechanisms of human disease. The chapter “Reflections and Outlook on Targeting HSP90, HSP70 and HSF1 in Cancer: A Personal Perspective” is available open access under a Creative Commons Attribution 4.0 International License via link.springer.com. Hard cover.
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HSF1 and Molecular Chaperones in Biology and Disease (Advances in Experimental Medicine and Biology (1243), Band 1243) (2020)
EN HC NW FEISBN: 9783030402037 bzw. 3030402037, in Englisch, Mendillo, Marc Laurence, Pincus, David, Scherz-Shouval, Ruth, Springer, gebundenes Buch, neu, Erstausgabe.
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Von Händler/Antiquariat, Amazon.de.
Springer, Gebundene Ausgabe, Ausgabe: 1st ed. 2020, Publiziert: 2020-06-01T00:00:01Z, Produktgruppe: Book.
Von Händler/Antiquariat, Amazon.de.
Springer, Gebundene Ausgabe, Ausgabe: 1st ed. 2020, Publiziert: 2020-06-01T00:00:01Z, Produktgruppe: Book.
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HSF1 and Molecular Chaperones in Biology and Disease Marc Laurence Mendillo Editor
~EN HC NWISBN: 9783030402037 bzw. 3030402037, vermutlich in Englisch, Springer International Publishing, gebundenes Buch, neu.
Lieferung aus: Vereinigte Staaten von Amerika, zzgl. Versandkosten.
HSF1 and Molecular Chaperones in Biology and Disease,Marc Laurence Mendillo.
HSF1 and Molecular Chaperones in Biology and Disease,Marc Laurence Mendillo.
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