Antiplasmodial activties of TMP-phenazines B4158 and B4119
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Antiplasmodial activties of TMP-phenazines B4158 and B4119 (2019)
~EN PB NWISBN: 9783330062535 bzw. 3330062533, vermutlich in Englisch, LAP Lambert Academic Publishing Mai 2019, Taschenbuch, neu.
Lieferung aus: Deutschland, Versandkostenfrei.
Von Händler/Antiquariat, AHA-BUCH GmbH [51283250], Einbeck, Germany.
Neuware - A novel flow cytometric procedure was established for use in evaluating the in vitro antimalarial activity oftetramethylpiperidine (TMP)- substituted phenazines. The flow cytometric procedure was compared with microscopy and radiometry for efficiency in quantitating the level of parasitemia in malaria cultures. The flow cytometric method compared well, as determined by the Bland and Altman measure of agreement, with both microscopy and radiometry and was chosen for use in this study due to its speed, precision and convenience (includes a fixing step that allows samples to be evaluated at anyone time). The TMP-substituted phenazines B4119 and B4158, synthetic derivatives of clofazimine, were evaluated extensively against a drug-sensitive and various drug-resistant lines ofPlasmodium jalciparum in vitro and against P. berghei in mice. Parasite growth was measured using microscopic and flow cytometric methods, while heme polymerization was investigated using an infrared spectroscopic procedure. The therapeutic potential of B4119 alone (30mg/kg/day), and in combination with a sub-therapeutic dose of chloroquine (l.251lg/kg/day) was measured in a murine model of experimental infection. 184 pp. Englisch.
Von Händler/Antiquariat, AHA-BUCH GmbH [51283250], Einbeck, Germany.
Neuware - A novel flow cytometric procedure was established for use in evaluating the in vitro antimalarial activity oftetramethylpiperidine (TMP)- substituted phenazines. The flow cytometric procedure was compared with microscopy and radiometry for efficiency in quantitating the level of parasitemia in malaria cultures. The flow cytometric method compared well, as determined by the Bland and Altman measure of agreement, with both microscopy and radiometry and was chosen for use in this study due to its speed, precision and convenience (includes a fixing step that allows samples to be evaluated at anyone time). The TMP-substituted phenazines B4119 and B4158, synthetic derivatives of clofazimine, were evaluated extensively against a drug-sensitive and various drug-resistant lines ofPlasmodium jalciparum in vitro and against P. berghei in mice. Parasite growth was measured using microscopic and flow cytometric methods, while heme polymerization was investigated using an infrared spectroscopic procedure. The therapeutic potential of B4119 alone (30mg/kg/day), and in combination with a sub-therapeutic dose of chloroquine (l.251lg/kg/day) was measured in a murine model of experimental infection. 184 pp. Englisch.
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Symbolbild
Antiplasmodial activties of TMP-phenazines B4158 and B4119
~EN PB NWISBN: 9783330062535 bzw. 3330062533, vermutlich in Englisch, LAP Lambert Academic Publishing, Taschenbuch, neu.
Lieferung aus: Deutschland, Versandkostenfrei.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
3
Antiplasmodial activties of TMP-phenazines B4158 and B4119 (2019)
~EN PB NWISBN: 9783330062535 bzw. 3330062533, vermutlich in Englisch, 184 Seiten, LAP Lambert Academic Publishing, Taschenbuch, neu.
Lieferung aus: Deutschland, Versandkosten nach: Deutschland, Versandkostenfrei.
Von Händler/Antiquariat, Syndikat Buchdienst, [4235284].
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Von Händler/Antiquariat, Syndikat Buchdienst, [4235284].
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
4
Antiplasmodial activties of TMP-phenazines B4158 and B4119 (2019)
EN PB NWISBN: 9783330062535 bzw. 3330062533, in Englisch, 184 Seiten, LAP LAMBERT Academic Publishing, Taschenbuch, neu.
Lieferung aus: Deutschland, Versandfertig in 1 - 2 Werktagen, Versandkostenfrei. Tatsächliche Versandkosten können abweichen.
Von Händler/Antiquariat, M & L aus Deutschland.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Von Händler/Antiquariat, M & L aus Deutschland.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
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