Falls Sie nur an einem bestimmten Exempar interessiert sind, können Sie aus der folgenden Liste jenes wählen, an dem Sie interessiert sind:
Nur diese Ausgabe anzeigen…
Nur diese Ausgabe anzeigen…
Identifying Novel Inborn Errors of the Immune System
9 Angebote vergleichen
Preise | Feb. 17 | März 19 | Sep. 19 |
---|---|---|---|
Schnitt | Fr. 38.42 (€ 39.26)¹ | Fr. 36.35 (€ 37.14)¹ | Fr. 45.30 (€ 46.28)¹ |
Nachfrage |
Identifying Novel Inborn Errors of the Immune System
ISBN: 9783658167967 bzw. 3658167963, in Deutsch, Springer Shop, neu, E-Book, elektronischer Download.
In her study Elisabeth Salzer describes three novel monogenic diseases. For CD27 deficiency Elisabeth Salzer describes a large cohort of patients. Although all patients shared the same causative missense mutation, they displayed diverse clinical presentations. In another patient she was able to identify a mutation in PRKCD resulting in a primary immunodeficiency with severe Lupus-like autoimmunity. The patient exhibited increased mRNA levels of IL6. Therefore, treatment with Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody was suggested. In a family with a history of deaths due to inflammatory bowel disease she identified a missense mutation in IL21. She produced wild type and mutated IL-21 protein and demonstrated a loss of function phenotype. As IL-21 is in clinical trials, she proposed a potentially curative treatment option. These discoveries contributed to the understanding of the multifaceted regulatory mechanisms of the immune system and highlighted essential players in these complex signaling networks. eBook.
Identifying Novel Inborn Errors of the Immune System
ISBN: 9783658167950 bzw. 3658167955, in Englisch, Springer, neu.
In her study Elisabeth Salzer describes three novel monogenic diseases. For CD27 deficiency Elisabeth Salzer describes a large cohort of patients. Although all patients shared the same causative missense mutation, they displayed diverse clinical presentations. In another patient she was able to identify a mutation in PRKCD resulting in a primary immunodeficiency with severe Lupus-like autoimmunity. The patient exhibited increased mRNA levels of IL6. Therefore, treatment with Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody was suggested. In a family with a history of deaths due to inflammatory bowel disease she identified a missense mutation in IL21. She produced wild type and mutated IL-21 protein and demonstrated a loss of function phenotype. As IL-21 is in clinical trials, she proposed a potentially curative treatment option. These discoveries contributed to the understanding of the multifaceted regulatory mechanisms of the immune system and highlighted essential players in these complex signaling networks.
Identifying Novel Inborn Errors of the Immune System - Primary Immunodeficiencies with Defective Class Switch and Autoimmunity
ISBN: 9783658167967 bzw. 3658167963, in Deutsch, Springer-Verlag, neu, E-Book, elektronischer Download.
In her study Elisabeth Salzer describes three novel monogenic diseases. For CD27 deficiency Elisabeth Salzer describes a large cohort of patients. Although all patients shared the same causative missense mutation, they displayed diverse clinical presentations. In another patient she was able to identify a mutation in PRKCD resulting in a primary immunodeficiency with severe Lupus-like autoimmunity. The patient exhibited increased mRNA levels of IL6 . Therefore, treatment with Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody was suggested. In a family with a history of deaths due to inflammatory bowel disease she identified a missense mutation in IL21 . She produced wild type and mutated IL-21 protein and demonstrated a loss of function phenotype. As IL-21 is in clinical trials, she proposed a potentially curative treatment option. These discoveries contributed to the understanding of the multifaceted regulatory mechanisms of the immune system and highlighted essential players in these complex signaling networks. Dr. Elisabeth Salzer works on the discovery and description of novel immunodeficiencies in children and adolescents at the CeMM Center for Molecular Medicine.
Identifying Novel Inborn Errors of the Immune System, Primary Immunodeficiencies with Defective Class Switch and Autoimmunity (2017)
ISBN: 9783658167950 bzw. 3658167955, in Deutsch, Springer, Taschenbuch, neu.
bol.com.
In her study Elisabeth Salzer describes three novel monogenic diseases. For CD27 deficiency Elisabeth Salzer describes a large cohort of patients. Although all patients shared the same causative missense mutation, they displayed diverse clinical presentations. In another patient she was able to identify a mutation in PRKCD resulting in a primary immunodeficiency with severe Lupus-like autoimmunity. The patient exhibited increased mRNA levels of IL6. Therefore, treatment with Tocilizumab, a human... In her study Elisabeth Salzer describes three novel monogenic diseases. For CD27 deficiency Elisabeth Salzer describes a large cohort of patients. Although all patients shared the same causative missense mutation, they displayed diverse clinical presentations. In another patient she was able to identify a mutation in PRKCD resulting in a primary immunodeficiency with severe Lupus-like autoimmunity. The patient exhibited increased mRNA levels of IL6. Therefore, treatment with Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody was suggested. In a family with a history of deaths due to inflammatory bowel disease she identified a missense mutation in IL21. She produced wild type and mutated IL-21 protein and demonstrated a loss of function phenotype. As IL-21 is in clinical trials, she proposed a potentially curative treatment option. These discoveries contributed to the understanding of the multifaceted regulatory mechanisms of the immune system and highlighted essential players in these complex signaling networks.Taal: Engels;Afmetingen: 210x148 mm;Verschijningsdatum: januari 2017;Druk: 1;ISBN10: 3658167955;ISBN13: 9783658167950; Engelstalig | Paperback | 2017.
Identifying Novel Inborn Errors of the Immune System
ISBN: 9783658167950 bzw. 3658167955, in Englisch, neu.
Primary Immunodeficiencies with Defective Class Switch and Autoimmunity, In her study Elisabeth Salzer describes three novel monogenic diseases. For CD27 deficiency Elisabeth Salzer describes a large cohort of patients. Although all patients shared the same causative missense mutation, they displayed diverse clinical presentations. In another patient she was able to identify a mutation in PRKCD resulting in a primary immunodeficiency with severe Lupus-like autoimmunity. The patient exhibited increased mRNA levels of IL6 . Therefore, treatment with Tocilizumab, a humanized anti-IL-6 receptor monoclonal antibody was suggested. In a family with a history of deaths due to inflammatory bowel disease she identified a missense mutation in IL21 . She produced wild type and mutated IL-21 protein and demonstrated a loss of function phenotype. As IL-21 is in clinical trials, she proposed a potentially curative treatment option. These discoveries contributed to the understanding of the multifaceted regulatory mechanisms of the immune system and highlighted essential players in these complex signaling networks.
Identifying Novel Inborn Errors of the Immune System (2017)
ISBN: 9783658167967 bzw. 3658167963, in Deutsch, Springer Fachmedien Wiesbaden, Taschenbuch, neu.
Identifying Novel Inborn Errors of the Immune System
ISBN: 9783658167967 bzw. 3658167963, vermutlich in Englisch, Gabler Betriebswirt.-Vlg, Taschenbuch, neu.
Identifying Novel Inborn Errors of the Immune System
ISBN: 9783658167967 bzw. 3658167963, vermutlich in Englisch, neu, E-Book, elektronischer Download.
Identifying Novel Inborn Errors of the Immune System : Primary Immunodeficiencies with Defective Class Switch and Autoimmunity
ISBN: 9783658167967 bzw. 3658167963, in Englisch, Springer Netherlands, neu, E-Book, elektronischer Download.