Nongenotoxic Carcinogenesis (Ernst Schering Foundation Symposium Proceedings Book 10) (English Edition)
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Lieferung aus: Italien, Lagernd, zzgl. Versandkosten.
"What is a nongenotoxic carcinogen?" This question recurred through­ out the Ernst Schering Research Foundation Workshop on nongeno­ toxic carcinogenesis, underlining the complexity of the topic. The clarity of the view that all carcinogens act by mutating DNA, origin­ ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer. There is an urgent need to in­ crease our understanding of these compounds so that their risks can be evaluated realistically and decisions made from a position of knowl­ edge and strength, rather than in fear of the unknown. A nongenotoxic carcinogen can be defined as a compound which causes cancer, but which does not cause damage to DNA as its primary biological activity. This negative definition covers a range of carci­ nogens acting through a variety of mechanisms. Such chemicals often produce tumours only in a single organ species, and there are a few common locations which are affected most often. For example, in male rats, certain carcinogens bind to az globulin to form a complex which 11 accumulates in the kidney tubular cells, which is followed by necrosis and compensatory cell proliferation leading the neoplasia. Other com­ mon mechanisms include hormonal imbalance resulting in thyroid tu­ mours or peroxisome proliferation resulting in liver cancer. These and other examples are studied in some detail in the papers of this book. eBook.

Lieferung aus: Deutschland, E-Book zum Download, Versandkostenfrei.
"What is a nongenotoxic carcinogen?" This question recurred through­ out the Ernst Schering Research Foundation Workshop on nongeno­ toxic carcinogenesis, underlining the complexity of the topic. The clarity of the view that all carcinogens act by mutating DNA, origin­ ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer. There is an urgent need to in­ crease our understanding of these compounds so that their risks can be evaluated realistically and decisions made from a position of knowl­ edge and strength, rather than in fear of the unknown. A nongenotoxic carcinogen can be defined as a compound which causes cancer, but which does not cause damage to DNA as its primary biological activity. This negative definition covers a range of carci­ nogens acting through a variety of mechanisms. Such chemicals often produce tumours only in a single organ species, and there are a few common locations which are affected most often. For example, in male rats, certain carcinogens bind to az globulin to form a complex which 11 accumulates in the kidney tubular cells, which is followed by necrosis and compensatory cell proliferation leading the neoplasia. Other com­ mon mechanisms include hormonal imbalance resulting in thyroid tu­ mours or peroxisome proliferation resulting in liver cancer. These and other examples are studied in some detail in the papers of this book. Kindle Ausgabe, Format: Kindle eBook, Label: Springer, Springer, Produktgruppe: eBooks, Publiziert: 2013-03-14, Freigegeben: 2013-03-14, Studio: Springer.

Lieferung aus: Deutschland, E-Book zum Download, Versandkostenfrei.
"What is a nongenotoxic carcinogen?" This question recurred through­ out the Ernst Schering Research Foundation Workshop on nongeno­ toxic carcinogenesis, underlining the complexity of the topic. The clarity of the view that all carcinogens act by mutating DNA, origin­ ally advocated by Bruce Ames nearly 20 years ago, has been clouded by the increasing numbers of compounds which are not genotoxic but which nevertheless can cause cancer. There is an urgent need to in­ crease our understanding of these compounds so that their risks can be evaluated realistically and decisions made from a position of knowl­ edge and strength, rather than in fear of the unknown. A nongenotoxic carcinogen can be defined as a compound which causes cancer, but which does not cause damage to DNA as its primary biological activity. This negative definition covers a range of carci­ nogens acting through a variety of mechanisms. Such chemicals often produce tumours only in a single organ species, and there are a few common locations which are affected most often. For example, in male rats, certain carcinogens bind to az globulin to form a complex which 11 accumulates in the kidney tubular cells, which is followed by necrosis and compensatory cell proliferation leading the neoplasia. Other com­ mon mechanisms include hormonal imbalance resulting in thyroid tu­ mours or peroxisome proliferation resulting in liver cancer. These and other examples are studied in some detail in the papers of this book. Kindle Edition, Format: Kindle eBook, Label: Springer, Springer, Produktgruppe: eBooks, Publiziert: 2013-03-14, Freigegeben: 2013-03-14, Studio: Springer.

Lieferung aus: Vereinigte Staaten von Amerika, Usually ships in 1-2 business days.
Von Händler/Antiquariat, Serendipity UnLtd.
The majority of human chemical carcinogens are capable of damaging DNA and are loosely defined as "genotoxic". On the other hand some chemicals which are described as non-genotoxic appear to increase the incidence of rodent cancers only as a secondary consequence of other induced toxicity. The primary action does not involve DNA damage. This book presents the concept of non-genotoxic carcinogenesis, including possible mechanisms of action. The papers presented by prominent workers provide a detailed insight into the complexity of the field. Hardcover, Ausgabe: 1, Label: Springer, Springer, Produktgruppe: Book, Publiziert: 1994-10-31, Studio: Springer.

Von Händler/Antiquariat, Bookbarn International [11757], Bristol, SOM, United Kingdom.
Ships from the UK within 24 hours. Your purchase supports authors through the Book Author Resale Right. No Dustjacket.

Lieferung aus: Brasilien, in-stock.
""What is a nongenotoxic carcinogen?" This question recurred through- out the Ernst Schering Research Foundation Workshop on nongeno- toxic carcinogenesis, underlining the complexity of the topic. The clarity of the view that all carcinog".

Lieferung aus: Frankreich, Expédition sous 1 à 2 jours ouvrés.
Von Händler/Antiquariat, tousbouquins.
Relié, Label: Springer-Verlag Berlin and Heidelberg GmbH & Co. K, Springer-Verlag Berlin and Heidelberg GmbH & Co. K, Produktgruppe: Book, Publiziert: 1994-11-01, Studio: Springer-Verlag Berlin and Heidelberg GmbH & Co. K.

Lieferung aus: Vereinigte Staaten von Amerika, Versandkostenfrei.
Von Händler/Antiquariat, Better World Books [51315977], Mishawaka, IN, U.S.A.
Former Library book. Great condition for a used book! Minimal wear.

Lieferung aus: Deutschland, Gewöhnlich versandfertig in 7 bis 11 Tagen.
Von Händler/Antiquariat, Amazon.de.
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