Porins of Lyme Disease and Relapsing Fever Spirochetes (Schriften zur Lyme-Borreliose)
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Schnitt | Fr. 41.50 (€ 42.46)¹ | Fr. 42.04 (€ 43.00)¹ | Fr. 45.11 (€ 46.14)¹ | Fr. 42.04 (€ 43.00)¹ |
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1
Porins of Lyme Disease and Relapsing Fever Spirochetes
DE PB NW
ISBN: 9783844101959 bzw. 3844101950, in Deutsch, Josef Eul Verlag GmbH, Taschenbuch, neu.
Lieferung aus: Deutschland, Versandkosten nach: Deutschland, Versandkostenfrei.
Von Händler/Antiquariat, buecher.de GmbH & Co. KG, [1].
The genus Borrelia belongs to the spirochete phylum, an ancient evolutionary branch of the domain bacteria that is only afar related to Gram-negative bacteria. All Borrelia species are obligate parasites and have a biphasic life cycle in common alternating between vertebrate hosts and their arthropod vectors. Borreliae can be subdivided into the agents of the two borrelian-caused human diseases, Lyme disease and relapsing fever.Due to the small 0.91 Mb chromosome, borreliae have a lack of biosynthetic capacity and limited metabolic pathways. Thus, all Borrelia species are highly dependent on nutrients provided by their hosts. The transport of nutrients and other molecules across the outer membrane of Gram-negative bacteria, such as Borrelia species, is enabled by pore-forming proteins, so-called porins.In one chapter of this study, the first identification and characterization of a relapsing fever porin, namely Oms38, is presented. A protein homologous to Oms38 was also identified in Lyme disease agents. Interestingly, this pore, designated as DipA, does not form a general diffusion pore but a channel with a binding-site specific for different dicarboxylates.In another set of experiments, it was shown that the porin P66 is present in both Lyme disease and relapsing fever species. The channel diameter and the constitution of Borrelia burgdorferi P66 were investigated in detail.Taking together, this thesis describes detailed biochemical and biophysical investigations of both Lyme disease and relapsing fever Borrelia porins and represents an important step forward in understanding the outer membrane pathways for nutrient uptake of these strictly host-dependent, pathogenic spirochetes. A profound knowledge of surface-exposed proteins, such as porins, is one precondition for the production of a successful vaccine and the drug design against the two borrelian-caused diseases. Versandfertig in 6-10 Tagen, Softcover, Neuware, offene Rechnung (Vorkasse vorbehalten).
Von Händler/Antiquariat, buecher.de GmbH & Co. KG, [1].
The genus Borrelia belongs to the spirochete phylum, an ancient evolutionary branch of the domain bacteria that is only afar related to Gram-negative bacteria. All Borrelia species are obligate parasites and have a biphasic life cycle in common alternating between vertebrate hosts and their arthropod vectors. Borreliae can be subdivided into the agents of the two borrelian-caused human diseases, Lyme disease and relapsing fever.Due to the small 0.91 Mb chromosome, borreliae have a lack of biosynthetic capacity and limited metabolic pathways. Thus, all Borrelia species are highly dependent on nutrients provided by their hosts. The transport of nutrients and other molecules across the outer membrane of Gram-negative bacteria, such as Borrelia species, is enabled by pore-forming proteins, so-called porins.In one chapter of this study, the first identification and characterization of a relapsing fever porin, namely Oms38, is presented. A protein homologous to Oms38 was also identified in Lyme disease agents. Interestingly, this pore, designated as DipA, does not form a general diffusion pore but a channel with a binding-site specific for different dicarboxylates.In another set of experiments, it was shown that the porin P66 is present in both Lyme disease and relapsing fever species. The channel diameter and the constitution of Borrelia burgdorferi P66 were investigated in detail.Taking together, this thesis describes detailed biochemical and biophysical investigations of both Lyme disease and relapsing fever Borrelia porins and represents an important step forward in understanding the outer membrane pathways for nutrient uptake of these strictly host-dependent, pathogenic spirochetes. A profound knowledge of surface-exposed proteins, such as porins, is one precondition for the production of a successful vaccine and the drug design against the two borrelian-caused diseases. Versandfertig in 6-10 Tagen, Softcover, Neuware, offene Rechnung (Vorkasse vorbehalten).
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Porins of Lyme Disease and Relapsing Fever Spirochetes (2012)
DE PB NW RP
ISBN: 9783844101959 bzw. 3844101950, in Deutsch, Josef Eul Verlag GmbH, Taschenbuch, neu, Nachdruck.
Lieferung aus: Deutschland, Versandkostenfrei.
Von Händler/Antiquariat, European-Media-Service Mannheim [1048135], Mannheim, Germany.
This item is printed on demand for shipment within 3 working days.
Von Händler/Antiquariat, European-Media-Service Mannheim [1048135], Mannheim, Germany.
This item is printed on demand for shipment within 3 working days.
4
Porins of Lyme Disease and Relapsing Fever Spirochetes (Schriften zur Lyme-Borreliose) (2012)
EN PB NW FE
ISBN: 9783844101959 bzw. 3844101950, in Englisch, 116 Seiten, Josef Eul Verlag, Taschenbuch, neu, Erstausgabe.
Lieferung aus: Deutschland, Gewöhnlich versandfertig in 24 Stunden, Versandkostenfrei. Tatsächliche Versandkosten können abweichen.
Von Händler/Antiquariat, josef-eul-verlag.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Von Händler/Antiquariat, josef-eul-verlag.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
5
Porins of Lyme Disease and Relapsing Fever Spirochetes (2012)
EN NW
ISBN: 9783844101959 bzw. 3844101950, in Englisch, 140 Seiten, Josef Eul Verlag Gmbh, neu.
Lieferung aus: Spanien, Temporalmente agotado. Haz tu pedido ahora y te lo enviaremos en cuanto esté disponible. Te enviaremos un e-mail con la fecha estimada de entrega tan pronto como tengamos información. No te haremos el cargo en la tarjeta de crédito hasta que se haya realizado el envío.
Von Händler/Antiquariat, Amazon.es.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Von Händler/Antiquariat, Amazon.es.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
6
Porins of Lyme Disease and Relapsing Fever Spirochetes (2012)
EN NW
ISBN: 9783844101959 bzw. 3844101950, in Englisch, 140 Seiten, Josef Eul Verlag Gmbh, neu.
Lieferung aus: Italien, Temporaneamente non disponibile. Se fai subito un ordine, effettueremo la consegna non appena sarà disponibile. Ti invieremo un'e-mail con una data di consegna stimata non appena avremo ulteriori informazioni. Non verranno effettuati addebiti sulla tua carta di credito fino alla spedizione dell'articolo.
Von Händler/Antiquariat, Amazon.it.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Von Händler/Antiquariat, Amazon.it.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
7
Porins of Lyme Disease and Relapsing Fever Spirochetes (2012)
DE PB NW
ISBN: 9783844101959 bzw. 3844101950, in Deutsch, Taschenbuch, neu.
Lieferung aus: Deutschland, Next Day, Versandkostenfrei.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
8
Porins of Lyme Disease and Relapsing Fever Spirochetes
DE PB NW
ISBN: 9783844101959 bzw. 3844101950, in Deutsch, Eul, J, Taschenbuch, neu.
Lieferung aus: Deutschland, Versandkosten nach: Deutschland.
Von Händler/Antiquariat, InternetBuchhandlung A. Bell, [3194875].
Taschenbuch, Neuware, Internationaler Versand, PayPal, Banküberweisung.
Von Händler/Antiquariat, InternetBuchhandlung A. Bell, [3194875].
Taschenbuch, Neuware, Internationaler Versand, PayPal, Banküberweisung.
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