D-type Cyclins and Cancer - 8 Angebote vergleichen
Bester Preis: Fr. 8.02 (€ 8.20)¹ (vom 10.03.2019)1
D-type Cyclins and Cancer
DE NW EB DL
ISBN: 9783319644516 bzw. 3319644513, in Deutsch, Springer-Verlag, neu, E-Book, elektronischer Download.
Lieferung aus: Deutschland, E-Book zum Download.
This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the retinoblastoma pathway to incorporate new evidence that suggests that cyclin D1s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases. Philip W. Hinds is Professor and Chair of the Department of Developmental, Molecular and Chemical Biology at Tufts University School of Medicine. He is also the Deputy Director of Tufts Medical Cancer Center. Dr. Hinds is an expert in cell cycle control and its dysregulation in cancer cells. He participates in several journal editorial boards including the Journal of Biological Chemistry, the Chinese Journal of Cancer , and Cancer Research to name a few. Nelson E. Brown is currently Associate Professor at the University of Talca School of Medicine in Chile. He is also Director of the Center for Medical Research at the University of Talca.? His current work focuses on the role of cyclin D1-associated kinase activity in senescence and tumorigenesis.
This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the retinoblastoma pathway to incorporate new evidence that suggests that cyclin D1s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases. Philip W. Hinds is Professor and Chair of the Department of Developmental, Molecular and Chemical Biology at Tufts University School of Medicine. He is also the Deputy Director of Tufts Medical Cancer Center. Dr. Hinds is an expert in cell cycle control and its dysregulation in cancer cells. He participates in several journal editorial boards including the Journal of Biological Chemistry, the Chinese Journal of Cancer , and Cancer Research to name a few. Nelson E. Brown is currently Associate Professor at the University of Talca School of Medicine in Chile. He is also Director of the Center for Medical Research at the University of Talca.? His current work focuses on the role of cyclin D1-associated kinase activity in senescence and tumorigenesis.
2
D-type Cyclins and Cancer (2018)
DE HC NW RP
ISBN: 9783319877976 bzw. 3319877976, in Deutsch, gebundenes Buch, neu, Nachdruck.
Lieferung aus: Deutschland, Next Day, Versandkostenfrei.
Erscheinungsdatum: 12.06.2018, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: D-type Cyclins and Cancer, Auflage: Softcover reprint of the original 1st ed. 2018, Redaktion: Brown, Nelson E. // Hinds, Philip W., Verlag: Springer International Publishing, Sprache: Englisch, Schlagworte: Onkologie // Molekularbiologie // Zellbiologie // Zytologie, Rubrik: Allgemeinmedizin // Diagnostik, Therapie, Seiten: 164, Informationen: Previously published in hardcover, Gewicht: 258 gr, Verkäufer: averdo.
Erscheinungsdatum: 12.06.2018, Medium: Taschenbuch, Einband: Kartoniert / Broschiert, Titel: D-type Cyclins and Cancer, Auflage: Softcover reprint of the original 1st ed. 2018, Redaktion: Brown, Nelson E. // Hinds, Philip W., Verlag: Springer International Publishing, Sprache: Englisch, Schlagworte: Onkologie // Molekularbiologie // Zellbiologie // Zytologie, Rubrik: Allgemeinmedizin // Diagnostik, Therapie, Seiten: 164, Informationen: Previously published in hardcover, Gewicht: 258 gr, Verkäufer: averdo.
3
D-type Cyclins and Cancer
~EN NW EB DL
ISBN: 9783319644516 bzw. 3319644513, vermutlich in Englisch, Springer Shop, neu, E-Book, elektronischer Download.
Lieferung aus: Vereinigtes Königreich Grossbritannien und Nordirland, Lagernd, zzgl. Versandkosten.
This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the “retinoblastoma pathway” to incorporate new evidence that suggests that cyclin D1’s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases. eBook.
This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide a thorough review of the latest discoveries on the new functions and interacting partners of mammalian cyclin Ds crucial to explain their oncogenic and differentiation properties in different cellular contexts. The volume begins with a historical perspective of how D-type cyclins were first discovered and eventually cloned from cancer tissues, followed by an account on the canonical functions of cyclin Ds during the G1-S transition of the cell cycle. Several chapters will be devoted to review the functions of D-type cyclins as transcriptional regulators and the mechanisms through which these novel functions could impact the tumorigenic process. Also discussed is emerging evidence that points to a role of D-type cyclins, particularly cyclin D1, as a cytoplasmic regulator of various cellular functions. This property, in human cells at least, is traceable to certain splice isoforms with novel oncogenic implications. Finally, a chapter is devoted to recent efforts to revise the canonical view of the “retinoblastoma pathway” to incorporate new evidence that suggests that cyclin D1’s role in G1 is to singly-phosphorylate the retinoblastoma protein (pRb) for discrimination of target protein interactions. This work represents a significant departure from the view of cyclin D1 as a negative regulator of pRb and may have critical implications for understanding the function of antineoplastic agents that target the cyclin D1-associated kinases. eBook.
4
D-type Cyclins and Cancer (2017)
EN NW EB DL
ISBN: 9783319644516 bzw. 3319644513, in Englisch, Humana Press, Humana Press, Humana Press, neu, E-Book, elektronischer Download.
Lieferung aus: Vereinigte Staaten von Amerika, in-stock.
This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide A.
This volume provides an integrated account of our current understanding of the functions of D-type cyclins during development and tumorigenesis, with special emphasis on the kinase-independent functions of these proteins. The volume will provide A.
6
D-type Cyclins and Cancer
DE PB NW
ISBN: 9783319877976 bzw. 3319877976, in Deutsch, Springer Shop, Taschenbuch, neu.
Lieferung aus: Vereinigtes Königreich Grossbritannien und Nordirland, Lagernd, zzgl. Versandkosten.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
7
/ Brown | D-type Cyclins and Cancer | Humana Press | Softcover reprint of the original 1st ed. 2018 | 2018
DE PB NW
ISBN: 9783319877976 bzw. 3319877976, in Deutsch, Humana Press, Taschenbuch, neu.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
8
Symbolbild
D-type Cyclins and Cancer
DE NW EB
ISBN: 9783319644516 bzw. 3319644513, in Deutsch, Springer Science+Business Media, neu, E-Book.
Lieferung aus: Deutschland, Lagernd, zzgl. Versandkosten.
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
Die Beschreibung dieses Angebotes ist von geringer Qualität oder in einer Fremdsprache. Trotzdem anzeigen
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